Great ideas! Let me add some basic options, for more group oriented playstyles.
Tank Runes
Unyielding Bulwark: Raise an immovable shield in front of you, blocking projectiles and melee attacks.
Titan’s Roar: Let out a powerful roar that taunts nearby enemies and boosts your defense.
Avalanche Stance: Plant your feet firmly, becoming immune to knockback and gaining resistance to crowd control effects.
Bulwark Charge: Charge forward with your shield raised, knocking back and stunning enemies in your path.
Thorn Fortress: Activate a stance that significantly reduces incoming damage and reflects a portion back at attackers.
Ironclad Resolve: Temporarily become invulnerable to all damage but unable to attack or move quickly.
Zoner Runes
Ethereal Cage: Summon an impenetrable spectral cage, around an area.
Duskshroud: Release a dense fog that reduces visibility and soundnoise in the area.
Frostfield: Creates a frozen area, causing both movement impediment and sustained ice damage.
Lightning Pillar: Place a pillar that intermittently emits staggering bolts of lightning.
Corruption Beacon: Set a beacon that weakens defenses and periodically pulses to apply a debuff that increases damage taken.
Ring of Embers: Summon multiple fireballs that orbit a designated area, that explode on contact.
Static Field: Create a static field that discharges electricity, damaging and briefly paralyzing enemies who remain inside.
Support / Healer Runes
Healing Mist: Release a mist that gradually restores health and dazes enemies within its range.
Purifying Light: Emit a beam of light that heals and dispels negative effects.
Restorative Barrier: Create a barrier that heals allies who stand within it while reducing the damage they take.
Blessed Aura: Emit an aura that increases the health regeneration rate of nearby allies.
Life Bond Link yourself to an ally, redirecting a portion of damage they take to you and gradually restoring their health.
Healing Ward: Place a ward that emits a healing light, slowly restoring health to allies and gradually dispelling ailments.
Guardian Spirit: Summon a protective spirit that follows an ally, absorbing a portion of damage dealt to them, turning it into healing upon the death of the target.
Radiant Shield: Provide a shield to an ally that absorbs damage and briefly blinds and staggers nearby enemies if broken.
Marker / Softener / Drainer Runes
Marking Shot: Fire a shot, that marks the target to increase the damage they take from all sources and make them visible through obstacles.
Sundering Strike: Hit an enemy to reduce their armor, making them more vulnerable to subsequent attacks.
Disorienting Flash: Release a flash of light that temporarily blinds and reveals enemies, making them easier to hit.
Draining Shot: Fire a shot that applies a poison, dealing increased damage and reducing the target’s resistances over time.
Vampiric Strike: Strike an enemy to siphon health, transferring a portion to you and reducing the enemy’s healing received.
Soul Sap: Cast a spell that drains Focus from an enemy and converts it into a temporary shield for you.
Curse of Agony: Apply a curse that deals damage over time and amplifies the effect of other damage over time effects. Stackable.
Curse of Frailty: Apply a curse that reduces the enemy’s movement speed and damage output.
Curse of Weakness: Apply a curse that reduces the target’s damage output and Stamina regeneration.
Controller Runes
Concussive Blast: Emit a blast that knocks back and disorients enemies, reducing their accuracy and movement speed.
Gravity Well: Create a gravity well that pulls enemies toward its center, slowing them down.
Binding Chains: Create chains that immobilize enemies and deal damage when they act.
Silencing Field: Place a field that silences enemies within it, preventing them from using abilities or casting spells.
Plague Grasp: Summon ghastly hands that emerge from the ground, gripping and dragging enemies towards you while inflicting plague damage.
Seismic Wave: Generate a seismic wave that knocks enemies off balance, disrupting movement.