When it comes to items that gain % of health/stamina/focus per hit - or which lose focus/stamina on being hit - the gains/losses seem huge.
With the chipped daggers machine gun rune, I can refill life and focus in a flash and never run out of stamina. I pinned the Echo Knight in the corner and just mashed the rune until he was dead, both phases. Maybe its just that rune that is broken, I dunno. Or maybe it was the rate at which the boss staggered. Still, having infinite life, stamina and focus made it feel almost trivial.