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runes should be extractable from unique (yellow) items
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you should be able to remove runes from item, destroying the rune but keeping the item
currently if i get good weapon with good animations then usualy it has bad first rune which is quite limiting and vice versa you may get weapon with great first rune but bad animations, by being able to destroy the rune freeing the slot it would make gearing way better and allow us to customize our builds
also this would make unique weapons litle more viable (currently they sucks, especialy when they have 2-3 useless abilities with medicore stats)