During the side quest to find Gordon when he leaves Sacrament, after finding him, if the player runs to the east to leave him he despawns while still in view of the camera and an enemy spawns in. I recall seeing it on my last playthrough too but didn’t get a video that time, so I think it consistently happens. It’s not a big deal but is a bit immersion breaking, and would be improved if the trigger for him to despawn was further away so it would happen off camera.
In the video you can see in the top left Gordon is still in view and despawns while an enemy spawns in: https://drive.google.com/file/d/1OCMd1yg8V8YdLmOgqH9_V-R9fg5Fg_HK/view?usp=sharing
Resolution is 2560x1440 [16:9].