Think of an optimized video game. A well optimized video game will run on any PC with decent specs. Now if that game was specialized to work only certain hardware, then that’s not really an optimized game. Anyway, this is just arguing semantics at this point.
Indestructible is not a dead affix at all. You can get affixes that boost damage, stamina, focus gain, heal amp and damage reduction based on durability which all are maximized by indestructible affix.
I have tested multiple masterworks sets against plagued sets for 3 three different builds and the difference is not noticeable.
And your set up will not work in any build that doesn’t have RoD and uses runes. You get hit once and you are losing 30 focus.