I got a weekly challenge that requires 2 Plague Ichor. I’m still relatively early, so Plague Ichor is valuable for my character’s progression. It feels bad to have one of my weekly challenges effectively lost because I randomly got a bad challenge.
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FWIW, the challenges doesn’t really give that much in rewards either way. But yea - the requirements vs. rewards kind of make little sense.
After the story you can get 2 from smaller boss versions in Meadows and Marin per their respawn (not sure if it’s a day or faster), not mentioning spiced plague outbreak rewards or crucible.