There are two issues that stand out in terms of quality of life issues.
First, there needs to be some kind of “lock” or other protection on items to prevent players from accidently selling, or destroying (by things like rune removal). While it only happened once before, and once with the new Breach content since I hadn’t played in a year. I could see this being a pretty big issue for some.
Also, a ‘buy back’ option might be good for things that aren’t locked that you changed your mind on.
Second, I know that I would love a “compare” feature on items. Sure, showing if something has higher or lower values is good, but what if they are completely different items and they don’t really compare like that? Say you are looking at a chest armor piece and you are considering changing from one wight to the next. Obviously the armor, poise, and weight will be different. But what about the stats? Currently you can only see stats on the thing you are looking at, not the thing equipped. Maybe an item of a different weight that you don’t normally wear in that slot has stats which make it better for your playstyle. It seems like the UI has plenty of room to have an activatable side-by-side comparison when highlighting items to compare ‘item x’ to what is equipped. (I would guess weapons would compare to the currently readied set, not all potentially 3 in the slot.)