My Utility Runes went missing and when I checked the rune vendor, they were locked.
I had to see the old man NPC at the rookery and pay Plague Ichore again to unlock them. I added my runes and went to crucible and later logged off.
Some time later when I opened the game again, the runes were gone. Locked again.
This happened all in one night. It started to get buggy when my character was stuck in looting animation and the model changed.